… DNA methyltransferase (DNMT) inhibitors azacytidine and decitabine are the most successful
epigenetic … DNA methylation is the most characterized epigenetic phenomenon described …

… the role of DNA methyltransferase inhibitors in the further development of epigenetic cancer
therapies… patterns can also be used to develop and refine epigenetic therapies for cancer. In …

… Abstract: DNA methylation is an epigenetic modification involved in gene expression
regulation. In cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

… DNMT. Given our increased understanding of the relationships between DNA methylation
and other mechanisms of epigenetic … proteins and histone modifications, there is now a need …

… are not the only potentially druggable targets for epigenetic therapies; however, epigenetic
… their development into the currently most advanced epigenetic drugs for clinical use. …

DNA methyltransferases (DNMTs) are promising epigenetic targets for the … DNMT inhibitors
(DNMTi) approved by the Food and Drug Administration of the United States for the treatment …

… the role of altered DNA methylation in cancer. Global hypomethylation in some models promotes
and in other models protects cancer … The complexity of DNA methylation makes hard to …

… lost DNA methylation to varying levels in 14 out of 15 cancer … This study highlights the
importance of DNA methylation … for cervical cancer and provides insight into the possible role of …

… the role of epigenetic modifications (DNA methylation, histone … new inhibitors (also called
epigenetic drugs), as well as their … inhibitors have the potential to be used in epigenetic therapy …

… between DNMT inhibitors and chemotherapeutic drugs make combining epigenetic therapy
and … Moreover, DNMT inhibitors can reverse epidermal growth factor (EGF) receptor (EGFR) …